TY - GEN
T1 - The effect of photoinitiator concentration on the physicochemical properties of hydrogel contact lenses
AU - McElroy, Deirdre M.
AU - Geever, Luke M.
AU - Higginbotham, Clement L.
AU - Devery, Sinead M.
N1 - Publisher Copyright:
© (2014) Trans Tech Publications, Switzerland.
PY - 2014
Y1 - 2014
N2 - Hydrogel soft contact lenses have been investigated as delivery systems for ophthalmic drug products in response to the need for more efficient ophthalmic drug delivery systems. Ocular drugs delivered via eye drops have a low residence time in the eye resulting in as low as 5% bioavailability of the therapeutic agent. This study investigates the effect of varying concentrations of the photoinitiator diphenyl (2,4,6-trimethylbenzoyl)-phosphine oxide (TPO) on the physicochemical properties of hydrogel soft contact lenses for ophthalmic drug delivery purposes. Contact lens samples were synthesised via photopolymerisation with a range of initiator concentration. Gel fraction and swelling results indicated that increasing the photoinitiator concentration increased the efficiency of the gel network and reduced the water content of contact lens samples. Fourier transform infra-red spectroscopy (FTIR) analysis was employed to confirm polymerisation of the lenses and also indicated the presence of residual photoinitiator in lenses with higher TPO concentrations.
AB - Hydrogel soft contact lenses have been investigated as delivery systems for ophthalmic drug products in response to the need for more efficient ophthalmic drug delivery systems. Ocular drugs delivered via eye drops have a low residence time in the eye resulting in as low as 5% bioavailability of the therapeutic agent. This study investigates the effect of varying concentrations of the photoinitiator diphenyl (2,4,6-trimethylbenzoyl)-phosphine oxide (TPO) on the physicochemical properties of hydrogel soft contact lenses for ophthalmic drug delivery purposes. Contact lens samples were synthesised via photopolymerisation with a range of initiator concentration. Gel fraction and swelling results indicated that increasing the photoinitiator concentration increased the efficiency of the gel network and reduced the water content of contact lens samples. Fourier transform infra-red spectroscopy (FTIR) analysis was employed to confirm polymerisation of the lenses and also indicated the presence of residual photoinitiator in lenses with higher TPO concentrations.
KW - Contact lenses
KW - Hydrogels
KW - Hydroxyethyl methacrylate
KW - N-Vinyl-2-pyrrolidinone
KW - Photoinitiator
UR - http://www.scopus.com/inward/record.url?scp=84920815167&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/AMM.679.118
DO - 10.4028/www.scientific.net/AMM.679.118
M3 - Conference contribution
AN - SCOPUS:84920815167
T3 - Applied Mechanics and Materials
SP - 118
EP - 127
BT - Engineering and Technology Research
A2 - Abdullah, Mohd Mustafa Al Bakri
A2 - Jamaludin, Liyana
A2 - Tahir, Muhammad Faheem Mohd
A2 - Hassan, Mohd Najmuddin Mohd
PB - Trans Tech Publications Ltd
T2 - 4th International Malaysia-Ireland Joint Symposium on Engineering, Science and Business, IMiEJS 2014
Y2 - 25 June 2014 through 26 June 2014
ER -