TY - GEN
T1 - Synthesis and characterization of polyethylene glycol dimethacrylate hydrogels for biomedical application
AU - Poplawska, Malgorzata
AU - Schimpf, Iska
AU - Brady, Damien
AU - Kealey, Carmel
AU - Mulvihill, Anne
AU - Higginbotham, Clement L.
N1 - Publisher Copyright:
© (2014) Trans Tech Publications, Switzerland.
PY - 2014
Y1 - 2014
N2 - Photo-polymerized polyethylene glycol dimethacrylate (PEGDMA) scaffolds were synthesized using two macromolecular monomers of 750 and 550 number average molecular weight. Variation in chain length of macromolecular monomers visibly influenced viscoelastic properties of the compositions, exhibiting an increase in shear storage and loss modulus in PEGDMA 750 hydrogels. Furthermore, water content in the pre-polymerization mixture was a main factor determining physical appearance of the samples, where increase in water content resulted in polymerization induced phase separation, demonstrated by opaqueness of preparations containing 60 and 75% (w/w) of H2O. In addition to this, swelling, gel fraction, compression and rheological measurements are found to be influenced by the amount of water incorporated in the hydrogels, resulting in the increased distance between polymer chains within the network. Furthermore this resulted in an apparent decrease in viscoelastic and mechanical properties of compositions, as well as in lowering their crosslinking density and compressive strength. Preliminary cytotoxicity results show no toxicity of the samples with approximately 80% cell viability after 24 h exposure of MC3T3-E1 Subclone 4 cells to the hydrogels, thus indicating that these materials could be potentially applied in the biomedical arena.
AB - Photo-polymerized polyethylene glycol dimethacrylate (PEGDMA) scaffolds were synthesized using two macromolecular monomers of 750 and 550 number average molecular weight. Variation in chain length of macromolecular monomers visibly influenced viscoelastic properties of the compositions, exhibiting an increase in shear storage and loss modulus in PEGDMA 750 hydrogels. Furthermore, water content in the pre-polymerization mixture was a main factor determining physical appearance of the samples, where increase in water content resulted in polymerization induced phase separation, demonstrated by opaqueness of preparations containing 60 and 75% (w/w) of H2O. In addition to this, swelling, gel fraction, compression and rheological measurements are found to be influenced by the amount of water incorporated in the hydrogels, resulting in the increased distance between polymer chains within the network. Furthermore this resulted in an apparent decrease in viscoelastic and mechanical properties of compositions, as well as in lowering their crosslinking density and compressive strength. Preliminary cytotoxicity results show no toxicity of the samples with approximately 80% cell viability after 24 h exposure of MC3T3-E1 Subclone 4 cells to the hydrogels, thus indicating that these materials could be potentially applied in the biomedical arena.
KW - Biomedical materials
KW - Hydrogels
KW - PEGDMA
UR - http://www.scopus.com/inward/record.url?scp=84920771855&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/AMM.679.158
DO - 10.4028/www.scientific.net/AMM.679.158
M3 - Conference contribution
AN - SCOPUS:84920771855
T3 - Applied Mechanics and Materials
SP - 158
EP - 170
BT - Engineering and Technology Research
A2 - Abdullah, Mohd Mustafa Al Bakri
A2 - Jamaludin, Liyana
A2 - Tahir, Muhammad Faheem Mohd
A2 - Hassan, Mohd Najmuddin Mohd
PB - Trans Tech Publications Ltd
T2 - 4th International Malaysia-Ireland Joint Symposium on Engineering, Science and Business, IMiEJS 2014
Y2 - 25 June 2014 through 26 June 2014
ER -