Stimuli-responsive biopolymeric systems for drug delivery to cancer cells

Viviane Seba; Gabriel Silva; Bor Shin Chee; Jeferson Gustavo Henn; Gabriel Goettende Lima; Zhi Cao; Mozart Marins; Michael Nugent

doi:10.1016/B978-0-12-821437-4.00014-1

Stimuli-responsive biopolymeric systems for drug delivery to cancer cells

Viviane Seba, Gabriel Silva, Bor Shin Chee, Jeferson Gustavo Henn, Gabriel Goettende Lima, Zhi Cao, Mozart Marins, Michael Nugent

Department of Polymer, Mechanical and Design

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Cancer is one of the highest causes of deaths in the world; however, cancer treatment faces several difficulties, such as resistance to multiple medications, serious side effects and toxicities, and lack of targeted action. One potential effective approach is the application of the stimuli-responsive biopolymeric systems. Since the tumor environment has specific characteristics, these systems could be used in delivering anticancer drugs to the intracellular environment of the tumor cells, while minimizing localized damage to healthy cells. Moreover, biopolymers have several advantages, including biocompatibility and nontoxicity and, additionally, could protect the drugs from degradation and provide a prolonged drug delivery. This chapter details the various stimuli-responsive biopolymeric systems that can be used for more efficient drug delivery to the cancer cells.

Original language	English
Title of host publication	Tailor-Made and Functionalized Biopolymer Systems
Subtitle of host publication	For Drug Delivery and Biomedical Applications
Publisher	Elsevier
Pages	663-704
Number of pages	42
ISBN (Electronic)	9780128214374
ISBN (Print)	9780128214374
DOIs	https://doi.org/10.1016/B978-0-12-821437-4.00014-1
Publication status	Published - 1 Jan 2021

Keywords

Biopolymers
Cancer
Drug delivery
Stimuli responsive
Targeted therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-821437-4.00014-1

Cite this

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abstract = "Cancer is one of the highest causes of deaths in the world; however, cancer treatment faces several difficulties, such as resistance to multiple medications, serious side effects and toxicities, and lack of targeted action. One potential effective approach is the application of the stimuli-responsive biopolymeric systems. Since the tumor environment has specific characteristics, these systems could be used in delivering anticancer drugs to the intracellular environment of the tumor cells, while minimizing localized damage to healthy cells. Moreover, biopolymers have several advantages, including biocompatibility and nontoxicity and, additionally, could protect the drugs from degradation and provide a prolonged drug delivery. This chapter details the various stimuli-responsive biopolymeric systems that can be used for more efficient drug delivery to the cancer cells.",

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AU - Seba, Viviane

AU - Silva, Gabriel

AU - Chee, Bor Shin

AU - Henn, Jeferson Gustavo

AU - Lima, Gabriel Goettende

AU - Cao, Zhi

AU - Marins, Mozart

AU - Nugent, Michael

PY - 2021/1/1

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N2 - Cancer is one of the highest causes of deaths in the world; however, cancer treatment faces several difficulties, such as resistance to multiple medications, serious side effects and toxicities, and lack of targeted action. One potential effective approach is the application of the stimuli-responsive biopolymeric systems. Since the tumor environment has specific characteristics, these systems could be used in delivering anticancer drugs to the intracellular environment of the tumor cells, while minimizing localized damage to healthy cells. Moreover, biopolymers have several advantages, including biocompatibility and nontoxicity and, additionally, could protect the drugs from degradation and provide a prolonged drug delivery. This chapter details the various stimuli-responsive biopolymeric systems that can be used for more efficient drug delivery to the cancer cells.

AB - Cancer is one of the highest causes of deaths in the world; however, cancer treatment faces several difficulties, such as resistance to multiple medications, serious side effects and toxicities, and lack of targeted action. One potential effective approach is the application of the stimuli-responsive biopolymeric systems. Since the tumor environment has specific characteristics, these systems could be used in delivering anticancer drugs to the intracellular environment of the tumor cells, while minimizing localized damage to healthy cells. Moreover, biopolymers have several advantages, including biocompatibility and nontoxicity and, additionally, could protect the drugs from degradation and provide a prolonged drug delivery. This chapter details the various stimuli-responsive biopolymeric systems that can be used for more efficient drug delivery to the cancer cells.

KW - Biopolymers

KW - Cancer

KW - Drug delivery

KW - Stimuli responsive

KW - Targeted therapy

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U2 - 10.1016/B978-0-12-821437-4.00014-1

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BT - Tailor-Made and Functionalized Biopolymer Systems

PB - Elsevier

ER -

Stimuli-responsive biopolymeric systems for drug delivery to cancer cells

Abstract

Keywords

UN SDGs

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