TY - JOUR
T1 - Preparation of biodegradable polyethylene glycol dimethacrylate hydrogels via thiol-ene chemistry
AU - Burke, Gavin
AU - Cao, Zhi
AU - Devine, Declan M.
AU - Major, Ian
N1 - Publisher Copyright:
© 2019 by the author.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Through the control of the molecular weight, water content and monomer concentration, polyethylene glycol dimethacrylate (PEGDMA) based hydrogels have been adapted for numerous applications, including as structural scaffolds, drug delivery vehicles and cell carriers. However, due to the low biodegradability rates, the use ofPEGDMAin tissue engineering has been limited. Thiol-based monomers have been shown to improve the degradation rates of several PEG-based hydrogels, though their impact on several material properties has not been as well defined. In this work, several mercaptopropianoates, as well as mercaptoacetates, were mixed with PEGDMA and copolymerized. Following an initial polymerization check, it was determined that mercaptoacetate-based thiol monomers did not polymerize in the presence of PEGDMA, whereas mercaptopropionates were more successful. The wettability, and the compressive and tensile strength, in addition to the thermal properties, were determined for successfully copolymerized samples via a combination of differential scanning calorimetry, dynamic mechanical analysis, unconfined compression, and goniometry. Further study determined that dipentaerythritol hexa(3-mercaptopropionate) (DiPETMP) successfully enhanced the biodegradability of PEGDMA.
AB - Through the control of the molecular weight, water content and monomer concentration, polyethylene glycol dimethacrylate (PEGDMA) based hydrogels have been adapted for numerous applications, including as structural scaffolds, drug delivery vehicles and cell carriers. However, due to the low biodegradability rates, the use ofPEGDMAin tissue engineering has been limited. Thiol-based monomers have been shown to improve the degradation rates of several PEG-based hydrogels, though their impact on several material properties has not been as well defined. In this work, several mercaptopropianoates, as well as mercaptoacetates, were mixed with PEGDMA and copolymerized. Following an initial polymerization check, it was determined that mercaptoacetate-based thiol monomers did not polymerize in the presence of PEGDMA, whereas mercaptopropionates were more successful. The wettability, and the compressive and tensile strength, in addition to the thermal properties, were determined for successfully copolymerized samples via a combination of differential scanning calorimetry, dynamic mechanical analysis, unconfined compression, and goniometry. Further study determined that dipentaerythritol hexa(3-mercaptopropionate) (DiPETMP) successfully enhanced the biodegradability of PEGDMA.
KW - Biodegradability
KW - Click chemistry
KW - PEGDMA
KW - Photopolymerisation
KW - Thiol monomers
KW - Thiol-ene
UR - http://www.scopus.com/inward/record.url?scp=85071168707&partnerID=8YFLogxK
U2 - 10.3390/polym11081339
DO - 10.3390/polym11081339
M3 - Article
AN - SCOPUS:85071168707
SN - 2073-4360
VL - 11
JO - Polymers
JF - Polymers
IS - 8
M1 - 1339
ER -