Photopolymerization for filling porous ceramic matrix: Improvement of mechanical properties and drug delivering behavior

María Canillas; Tess Geever; Katilayne Vieira; Michael J.D. Nugent; John A. Killion; Declan M. Devine; Miguel A. Rodríguez

doi:10.1002/pc.24914

Photopolymerization for filling porous ceramic matrix: Improvement of mechanical properties and drug delivering behavior

María Canillas, Tess Geever, Katilayne Vieira, Michael J.D. Nugent, John A. Killion, Declan M. Devine, Miguel A. Rodríguez

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

This work presents the photopolymerisation of composite scaffolds where a prefabricated ceramic scaffold was impregnated with poly(ethylene) glycol dimethacrylate (PEGDMA) macromonomer solution. The PEGDMA solution penetrates the porosity of ceramic scaffold where it cures in situ thereby enhancing their mechanical properties. The mechanical properties of the obtained composite approximate the mechanical properties of cancellous bone. The Young´s Modulus of the composite developed is 106 ± 5 MPa. PEGDMA is a polymer that shows excellent percentages of gel fraction (96%), which preserves when ceramic scaffold is introduced, and swelling (134%). Furthermore, thanks to their swelling properties, the composite is able to control the release vancomycin and dexamethasone. The efficacy of in situ delivery of vancomycin is demonstrated by the inhibition of bacteria colony proliferation. Dexamethasone released is recorded for up to 10 days using ultra violet-visible spectroscopy. These excellent results make photopolymerization and PEGDMA strong candidates for the manufacture of different loaded bone void fillers. POLYM. COMPOS., 40:1654–1662, 2019.

Original language	English
Pages (from-to)	1654-1662
Number of pages	9
Journal	Polymer Composites
Volume	40
Issue number	4
DOIs	https://doi.org/10.1002/pc.24914
Publication status	Published - Apr 2019

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title = "Photopolymerization for filling porous ceramic matrix: Improvement of mechanical properties and drug delivering behavior",

abstract = "This work presents the photopolymerisation of composite scaffolds where a prefabricated ceramic scaffold was impregnated with poly(ethylene) glycol dimethacrylate (PEGDMA) macromonomer solution. The PEGDMA solution penetrates the porosity of ceramic scaffold where it cures in situ thereby enhancing their mechanical properties. The mechanical properties of the obtained composite approximate the mechanical properties of cancellous bone. The Young´s Modulus of the composite developed is 106 ± 5 MPa. PEGDMA is a polymer that shows excellent percentages of gel fraction (96%), which preserves when ceramic scaffold is introduced, and swelling (134%). Furthermore, thanks to their swelling properties, the composite is able to control the release vancomycin and dexamethasone. The efficacy of in situ delivery of vancomycin is demonstrated by the inhibition of bacteria colony proliferation. Dexamethasone released is recorded for up to 10 days using ultra violet-visible spectroscopy. These excellent results make photopolymerization and PEGDMA strong candidates for the manufacture of different loaded bone void fillers. POLYM. COMPOS., 40:1654–1662, 2019.",

author = "Mar{\'i}a Canillas and Tess Geever and Katilayne Vieira and Nugent, {Michael J.D.} and Killion, {John A.} and Devine, {Declan M.} and Rodr{\'i}guez, {Miguel A.}",

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AU - Canillas, María

AU - Geever, Tess

AU - Vieira, Katilayne

AU - Nugent, Michael J.D.

AU - Killion, John A.

AU - Devine, Declan M.

AU - Rodríguez, Miguel A.

PY - 2019/4

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N2 - This work presents the photopolymerisation of composite scaffolds where a prefabricated ceramic scaffold was impregnated with poly(ethylene) glycol dimethacrylate (PEGDMA) macromonomer solution. The PEGDMA solution penetrates the porosity of ceramic scaffold where it cures in situ thereby enhancing their mechanical properties. The mechanical properties of the obtained composite approximate the mechanical properties of cancellous bone. The Young´s Modulus of the composite developed is 106 ± 5 MPa. PEGDMA is a polymer that shows excellent percentages of gel fraction (96%), which preserves when ceramic scaffold is introduced, and swelling (134%). Furthermore, thanks to their swelling properties, the composite is able to control the release vancomycin and dexamethasone. The efficacy of in situ delivery of vancomycin is demonstrated by the inhibition of bacteria colony proliferation. Dexamethasone released is recorded for up to 10 days using ultra violet-visible spectroscopy. These excellent results make photopolymerization and PEGDMA strong candidates for the manufacture of different loaded bone void fillers. POLYM. COMPOS., 40:1654–1662, 2019.

AB - This work presents the photopolymerisation of composite scaffolds where a prefabricated ceramic scaffold was impregnated with poly(ethylene) glycol dimethacrylate (PEGDMA) macromonomer solution. The PEGDMA solution penetrates the porosity of ceramic scaffold where it cures in situ thereby enhancing their mechanical properties. The mechanical properties of the obtained composite approximate the mechanical properties of cancellous bone. The Young´s Modulus of the composite developed is 106 ± 5 MPa. PEGDMA is a polymer that shows excellent percentages of gel fraction (96%), which preserves when ceramic scaffold is introduced, and swelling (134%). Furthermore, thanks to their swelling properties, the composite is able to control the release vancomycin and dexamethasone. The efficacy of in situ delivery of vancomycin is demonstrated by the inhibition of bacteria colony proliferation. Dexamethasone released is recorded for up to 10 days using ultra violet-visible spectroscopy. These excellent results make photopolymerization and PEGDMA strong candidates for the manufacture of different loaded bone void fillers. POLYM. COMPOS., 40:1654–1662, 2019.

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Photopolymerization for filling porous ceramic matrix: Improvement of mechanical properties and drug delivering behavior

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