Abstract
Cancer is a group of complex diseases that have chemotherapy as standard approach to treat the pathologies. However, its treatment has several limitations, such as high systemic toxicity, insufficient quantity of delivered therapeutics, nonspecific biodistribution, and delivery of drugs to healthy tissue. Ongoing studies have been performed to achieve efficient and safer therapeutics to treat cancer, including formulations with bioactive molecules and conventional drugs. To accomplish the ideal delivery of these, it is crucial to apply appropriate drug delivery systems; one promising example is polysaccharide-based delivery systems. Polysaccharide bioproducts can achieve favorable properties such as optimal size and solubility. Moreover, they can be produced to improve the drug circulation time, and if designed with adequate biomarkers, they can reach the tumor site targeting unhealthy cells and decrease the traditional side effects of chemotherapy. This chapter focuses on the delivery of therapeutics to treat cancer, utilizing polysaccharide-based drug delivery systems.
| Original language | English |
|---|---|
| Title of host publication | Natural Polysaccharides in Drug Delivery and Biomedical Applications |
| Publisher | Elsevier |
| Pages | 441-470 |
| Number of pages | 30 |
| ISBN (Electronic) | 9780128170557 |
| ISBN (Print) | 9780128170557 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
Keywords
- Anticancer drug delivery
- Cancer therapy
- Drug delivery systems
- Polysaccharides
- Polysaccharides delivery
