Melt processed polymer blends for potential regenerative medicine applications

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

There is an urgent and unmet requirement for biocompatible and biodegradable implants that gradually resorb when implanted in vivo. This study examines the potential of melt extruded thermoplastics polyethylene oxide (PEO) and polycaprolactone (PCL) in the area of regenerative medicine. Various ratios of PEO and PCL were melt blended and analysed in order to obtain an optimised breakdown rate. Subsequently the effect of varying the molecular weight of PCL using a constant molecular weight PEO was also examined. Samples were characterised using melt flow index (MFI), differential scanning calorimetry (DSC) and breakdown analysis. It was found that by altering both the concentrations of PEO/PCL and the molecular weight of PCL, melt viscosity, breakdown rate and thermal properties could be modulated to produce potential implant materials with a tailored breakdown rate.

Original languageEnglish
Title of host publicationEngineering and Technology Research
EditorsMohd Mustafa Al Bakri Abdullah, Liyana Jamaludin, Muhammad Faheem Mohd Tahir, Mohd Najmuddin Mohd Hassan
PublisherTrans Tech Publications Ltd
Pages92-100
Number of pages9
ISBN (Electronic)9783038352792
DOIs
Publication statusPublished - 2014
Event4th International Malaysia-Ireland Joint Symposium on Engineering, Science and Business, IMiEJS 2014 - Penang, Malaysia
Duration: 25 Jun 201426 Jun 2014

Publication series

NameApplied Mechanics and Materials
Volume679
ISSN (Print)1660-9336
ISSN (Electronic)1662-7482

Conference

Conference4th International Malaysia-Ireland Joint Symposium on Engineering, Science and Business, IMiEJS 2014
Country/TerritoryMalaysia
CityPenang
Period25/06/1426/06/14

Keywords

  • Bioresorbable scaffold
  • Hot melt extrusion
  • Polycaprolactone
  • Polyethylene oxide

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