TY - GEN
T1 - Melt processed polymer blends for potential regenerative medicine applications
AU - Kenny, Elaine
AU - Devine, Declan M.
AU - Higginbotham, Clement L.
AU - Geever, Luke M.
N1 - Publisher Copyright:
© (2014) Trans Tech Publications, Switzerland.
PY - 2014
Y1 - 2014
N2 - There is an urgent and unmet requirement for biocompatible and biodegradable implants that gradually resorb when implanted in vivo. This study examines the potential of melt extruded thermoplastics polyethylene oxide (PEO) and polycaprolactone (PCL) in the area of regenerative medicine. Various ratios of PEO and PCL were melt blended and analysed in order to obtain an optimised breakdown rate. Subsequently the effect of varying the molecular weight of PCL using a constant molecular weight PEO was also examined. Samples were characterised using melt flow index (MFI), differential scanning calorimetry (DSC) and breakdown analysis. It was found that by altering both the concentrations of PEO/PCL and the molecular weight of PCL, melt viscosity, breakdown rate and thermal properties could be modulated to produce potential implant materials with a tailored breakdown rate.
AB - There is an urgent and unmet requirement for biocompatible and biodegradable implants that gradually resorb when implanted in vivo. This study examines the potential of melt extruded thermoplastics polyethylene oxide (PEO) and polycaprolactone (PCL) in the area of regenerative medicine. Various ratios of PEO and PCL were melt blended and analysed in order to obtain an optimised breakdown rate. Subsequently the effect of varying the molecular weight of PCL using a constant molecular weight PEO was also examined. Samples were characterised using melt flow index (MFI), differential scanning calorimetry (DSC) and breakdown analysis. It was found that by altering both the concentrations of PEO/PCL and the molecular weight of PCL, melt viscosity, breakdown rate and thermal properties could be modulated to produce potential implant materials with a tailored breakdown rate.
KW - Bioresorbable scaffold
KW - Hot melt extrusion
KW - Polycaprolactone
KW - Polyethylene oxide
UR - http://www.scopus.com/inward/record.url?scp=84920760719&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/AMM.679.92
DO - 10.4028/www.scientific.net/AMM.679.92
M3 - Conference contribution
AN - SCOPUS:84920760719
T3 - Applied Mechanics and Materials
SP - 92
EP - 100
BT - Engineering and Technology Research
A2 - Abdullah, Mohd Mustafa Al Bakri
A2 - Jamaludin, Liyana
A2 - Tahir, Muhammad Faheem Mohd
A2 - Hassan, Mohd Najmuddin Mohd
PB - Trans Tech Publications Ltd
T2 - 4th International Malaysia-Ireland Joint Symposium on Engineering, Science and Business, IMiEJS 2014
Y2 - 25 June 2014 through 26 June 2014
ER -