Melt Extruded Bioresorbable Polymer Composites for Potential Regenerative Medicine Applications

Elaine K. Kenny; Noel M. Gately; John A. Killion; Declan M. Devine; Clement L. Higginbotham; Luke M. Geever

doi:10.1080/03602559.2015.1098684

Melt Extruded Bioresorbable Polymer Composites for Potential Regenerative Medicine Applications

Elaine K. Kenny, Noel M. Gately, John A. Killion, Declan M. Devine, Clement L. Higginbotham, Luke M. Geever

Limerick Institute of Technology,

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Biodegradable polymers—polyethylene oxide and poly (ϵ-caprolactone)—were melt extruded with β-tricalcium phosphate. Breakdown analysis revealed that the percentage increase in bioceramic caused a prolonged degradation rate, with samples containing 20 wt% β-tricalcium phosphate losing significantly less weight over time in comparison to the control sample. Compression testing of samples following submission in aqueous environments revealed the composites exhibited enhanced strength with increasing bioceramic loading. The mechanical properties were significantly reduced over a period of 5 weeks. It was found that hot-melt extrusion of β-tricalcium phosphate is a viable and effective method of producing novel composite scaffolds with potential for regenerative medicine applications.

Original language	English
Pages (from-to)	432-446
Number of pages	15
Journal	Polymer - Plastics Technology and Engineering
Volume	55
Issue number	4
DOIs	https://doi.org/10.1080/03602559.2015.1098684
Publication status	Published - 3 Mar 2016

Keywords

hot-melt extrusion
regenerative medicine
β-tricalcium phosphate

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10.1080/03602559.2015.1098684

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abstract = "Biodegradable polymers—polyethylene oxide and poly (ϵ-caprolactone)—were melt extruded with β-tricalcium phosphate. Breakdown analysis revealed that the percentage increase in bioceramic caused a prolonged degradation rate, with samples containing 20 wt% β-tricalcium phosphate losing significantly less weight over time in comparison to the control sample. Compression testing of samples following submission in aqueous environments revealed the composites exhibited enhanced strength with increasing bioceramic loading. The mechanical properties were significantly reduced over a period of 5 weeks. It was found that hot-melt extrusion of β-tricalcium phosphate is a viable and effective method of producing novel composite scaffolds with potential for regenerative medicine applications.",

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T1 - Melt Extruded Bioresorbable Polymer Composites for Potential Regenerative Medicine Applications

AU - Kenny, Elaine K.

AU - Gately, Noel M.

AU - Killion, John A.

AU - Devine, Declan M.

AU - Higginbotham, Clement L.

AU - Geever, Luke M.

PY - 2016/3/3

Y1 - 2016/3/3

N2 - Biodegradable polymers—polyethylene oxide and poly (ϵ-caprolactone)—were melt extruded with β-tricalcium phosphate. Breakdown analysis revealed that the percentage increase in bioceramic caused a prolonged degradation rate, with samples containing 20 wt% β-tricalcium phosphate losing significantly less weight over time in comparison to the control sample. Compression testing of samples following submission in aqueous environments revealed the composites exhibited enhanced strength with increasing bioceramic loading. The mechanical properties were significantly reduced over a period of 5 weeks. It was found that hot-melt extrusion of β-tricalcium phosphate is a viable and effective method of producing novel composite scaffolds with potential for regenerative medicine applications.

AB - Biodegradable polymers—polyethylene oxide and poly (ϵ-caprolactone)—were melt extruded with β-tricalcium phosphate. Breakdown analysis revealed that the percentage increase in bioceramic caused a prolonged degradation rate, with samples containing 20 wt% β-tricalcium phosphate losing significantly less weight over time in comparison to the control sample. Compression testing of samples following submission in aqueous environments revealed the composites exhibited enhanced strength with increasing bioceramic loading. The mechanical properties were significantly reduced over a period of 5 weeks. It was found that hot-melt extrusion of β-tricalcium phosphate is a viable and effective method of producing novel composite scaffolds with potential for regenerative medicine applications.

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Melt Extruded Bioresorbable Polymer Composites for Potential Regenerative Medicine Applications

Abstract

Keywords

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