Influence of the presence of a gel in the water phase on the electrochemical transfer of ionic forms of β-blockers across a large water|1,2-dichloroethane interface

Sebastien Fantini, Jason Clohessy, Karine Gorgy, Florence Fusalba, Christoffer Johans, Kyösti Kontturi, Vincent J. Cunnane

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)

    Abstract

    The transfer of ionic species of three β-blockers (propranolol, sotalol and timolol) has been studied by cyclic voltammetry at a macroscopic water|1,2-dichloroethane (1,2-DCE) interface. The aqueous solution has been gellified in order to study the effect of the gel on the transport properties of the drugs. The gelling agent also stabilizes the interface overcoming mechanical instability. The standard potential and standard Gibbs energy of transfer across the interface, the partition coefficient and the diffusion coefficient of each drug were determined in the presence of a gelled interface. The diffusion coefficients were shifted relative to those obtained at normal water|1,2-DCE interfaces (free of gel).

    Original languageEnglish
    Pages (from-to)251-257
    Number of pages7
    JournalEuropean Journal of Pharmaceutical Sciences
    Volume18
    Issue number3-4
    DOIs
    Publication statusPublished - Mar 2003

    Keywords

    • Diffusion coefficient
    • Drug transfer
    • Gelled aqueous solution
    • ITIES
    • Lipophilicity
    • β-Blockers

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