Hydrogels for arterial modelling and tissue scaffolding

Aimee Dunne, Austin B. Coffey, Niall Murphy, Philip R. Walsh, Rachel Walsh, Seán Lyons

    Research output: Contribution to conferencePaperpeer-review

    Abstract

    Models of human blood vessels have many potential applications as aids in continuing research on new medical devices. The work detailed herein describes the development of a hydrogel material to mimic the mechanical and biological response of a range of human arteries. The developed hydrogels were characterized via swelling studies, differential calorimetry and spectroscopic techniques, while viscoelastic property measurement was investigated primarily using rheological testing methods. A range HEMA/NVP hydrogel materials were successfully developed with properties comparable to a range of arteries, namely, the thoracic and abdominal aorta with storage moduli (G′) varying from 43kPa to 64kPa depending on the formulation. This paper also describes the construction of a mathematical model for the viscoelastic properties of these materials, representing the time-dependent behaviour of the simulated areterial material when subjected to loading and unloading phenomena.

    Original languageEnglish
    Pages1859-1864
    Number of pages6
    Publication statusPublished - 2014
    Event72nd Annual Technical Conference of the Society of Plastics Engineers: The Plastics Conference, ANTEC 2014 - Las Vegas, United States
    Duration: 28 Apr 201430 Apr 2014

    Conference

    Conference72nd Annual Technical Conference of the Society of Plastics Engineers: The Plastics Conference, ANTEC 2014
    Country/TerritoryUnited States
    CityLas Vegas
    Period28/04/1430/04/14

    Keywords

    • Arterial modeling
    • Biomedical
    • Hydrogel
    • Medical device
    • Medical polymers
    • Viscoelasticity

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