Freeze-thaw electrospun PVA-dacarbazine nanoparticles: preparation, characterization and anticancer evaluation

Luiza Steffens Reinhardt; Bor Shin Chee; Zhi Cao; Dinara Jaqueline Moura; Michael Nugent

doi:10.1080/00914037.2019.1605606

Freeze-thaw electrospun PVA-dacarbazine nanoparticles: preparation, characterization and anticancer evaluation

Luiza Steffens Reinhardt, Bor Shin Chee, Zhi Cao, Dinara Jaqueline Moura, Michael Nugent

Department of Polymer, Mechanical and Design

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Dacarbazine (DTIC) is an antitumor agent that has limited clinical applications due to its insolubility, instability and toxicity to normal cells. One possibility to achieve controlled release is PVA-based NPs. This work presents electrospun NPs that combines PVA and DTIC. The results showed that DTIC NPs had mean particle sizes of 458.2 ± 113.6 nm, suggested the presence of DTIC in an amorphous state and showed a burst in vitro drug release followed by constant release. The cytotoxicity evaluation showed that DTIC NPs were effective against glioblastoma cells. This study indicates that the formulated NPs improved DTIC solubility and efficacy.

Original language	English
Pages (from-to)	749-760
Number of pages	12
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	69
Issue number	12
DOIs	https://doi.org/10.1080/00914037.2019.1605606
Publication status	Published - 12 Aug 2020

Keywords

Anticancer activity
Dacarbazine
electrospinning
freeze-thaw
nanoparticles
polyvinyl alcohol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/00914037.2019.1605606

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title = "Freeze-thaw electrospun PVA-dacarbazine nanoparticles: preparation, characterization and anticancer evaluation",

abstract = "Dacarbazine (DTIC) is an antitumor agent that has limited clinical applications due to its insolubility, instability and toxicity to normal cells. One possibility to achieve controlled release is PVA-based NPs. This work presents electrospun NPs that combines PVA and DTIC. The results showed that DTIC NPs had mean particle sizes of 458.2 ± 113.6 nm, suggested the presence of DTIC in an amorphous state and showed a burst in vitro drug release followed by constant release. The cytotoxicity evaluation showed that DTIC NPs were effective against glioblastoma cells. This study indicates that the formulated NPs improved DTIC solubility and efficacy.",

keywords = "Anticancer activity, Dacarbazine, electrospinning, freeze-thaw, nanoparticles, polyvinyl alcohol",

author = "{Steffens Reinhardt}, Luiza and Chee, {Bor Shin} and Zhi Cao and {Jaqueline Moura}, Dinara and Michael Nugent",

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T1 - Freeze-thaw electrospun PVA-dacarbazine nanoparticles

T2 - preparation, characterization and anticancer evaluation

AU - Steffens Reinhardt, Luiza

AU - Chee, Bor Shin

AU - Cao, Zhi

AU - Jaqueline Moura, Dinara

AU - Nugent, Michael

PY - 2020/8/12

Y1 - 2020/8/12

N2 - Dacarbazine (DTIC) is an antitumor agent that has limited clinical applications due to its insolubility, instability and toxicity to normal cells. One possibility to achieve controlled release is PVA-based NPs. This work presents electrospun NPs that combines PVA and DTIC. The results showed that DTIC NPs had mean particle sizes of 458.2 ± 113.6 nm, suggested the presence of DTIC in an amorphous state and showed a burst in vitro drug release followed by constant release. The cytotoxicity evaluation showed that DTIC NPs were effective against glioblastoma cells. This study indicates that the formulated NPs improved DTIC solubility and efficacy.

AB - Dacarbazine (DTIC) is an antitumor agent that has limited clinical applications due to its insolubility, instability and toxicity to normal cells. One possibility to achieve controlled release is PVA-based NPs. This work presents electrospun NPs that combines PVA and DTIC. The results showed that DTIC NPs had mean particle sizes of 458.2 ± 113.6 nm, suggested the presence of DTIC in an amorphous state and showed a burst in vitro drug release followed by constant release. The cytotoxicity evaluation showed that DTIC NPs were effective against glioblastoma cells. This study indicates that the formulated NPs improved DTIC solubility and efficacy.

KW - Anticancer activity

KW - Dacarbazine

KW - electrospinning

KW - freeze-thaw

KW - nanoparticles

KW - polyvinyl alcohol

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U2 - 10.1080/00914037.2019.1605606

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M3 - Article

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JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

IS - 12

ER -

Freeze-thaw electrospun PVA-dacarbazine nanoparticles: preparation, characterization and anticancer evaluation

Abstract

Keywords

UN SDGs

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