TY - JOUR
T1 - Development of chemically cross-linked hydrophilic-hydrophobic hydrogels for drug delivery applications
AU - Barron, Valerie
AU - Killion, John A.
AU - Pilkington, Laura
AU - Burke, Gavin
AU - Geever, Luke M.
AU - Lyons, John G.
AU - McCullagh, Edwin
AU - Higginbotham, Clement L.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/2
Y1 - 2016/2
N2 - The main aim of this study was to examine the potential of hydrophlilic-hydrophobic chemically crosslinked polymers as vehicles for drug delivery. To this end, a range of polypropyleneglycol dimethacrylate/polyethyleneglycol dimethacrylate (PPGDMA/PEGDMA) and polypropyleneglycol diacrylate/polyethyleneglycol dimethacrylate (PPGDA/PEGDMA) hydrogels were photopolymerised using UV light. Thereafter, the chemical, rheological and mechanical properties were evaluated, where it was revealed that the presence of the methyl group on the PPGDMA/PEGDMA hydrogel had no statistically significant effect on the gel fraction, storage loss modulus, or tan delta. In terms of mechanical properties, the 75 wt% PPGDMA/PEGDMA and PPGDA/PEGDMA hydrogels had the highest compressive modulus, with values of 9.02 MPa and 8.47 MPa recorded respectively. Drug release was examined for two anti-inflammatory agents; dexamethasone and diclofenac sodium, where it was revealed that the concentration of the PPGDA in the PPGDA/PEGDMA had no significant effect on the release profile of dexamethasone. However, the size and interaction of the drug with the hydrogel appears to alter the release profile, as the larger, acidic dexamethasone drug was eluted faster than the smaller, ionic, basic diclofenac sodium agent.
AB - The main aim of this study was to examine the potential of hydrophlilic-hydrophobic chemically crosslinked polymers as vehicles for drug delivery. To this end, a range of polypropyleneglycol dimethacrylate/polyethyleneglycol dimethacrylate (PPGDMA/PEGDMA) and polypropyleneglycol diacrylate/polyethyleneglycol dimethacrylate (PPGDA/PEGDMA) hydrogels were photopolymerised using UV light. Thereafter, the chemical, rheological and mechanical properties were evaluated, where it was revealed that the presence of the methyl group on the PPGDMA/PEGDMA hydrogel had no statistically significant effect on the gel fraction, storage loss modulus, or tan delta. In terms of mechanical properties, the 75 wt% PPGDMA/PEGDMA and PPGDA/PEGDMA hydrogels had the highest compressive modulus, with values of 9.02 MPa and 8.47 MPa recorded respectively. Drug release was examined for two anti-inflammatory agents; dexamethasone and diclofenac sodium, where it was revealed that the concentration of the PPGDA in the PPGDA/PEGDMA had no significant effect on the release profile of dexamethasone. However, the size and interaction of the drug with the hydrogel appears to alter the release profile, as the larger, acidic dexamethasone drug was eluted faster than the smaller, ionic, basic diclofenac sodium agent.
KW - Dexamethasone
KW - Diclofenac sodium
KW - Drug release
KW - Hydrophilic-hydrophobic hydrogel
KW - Polyethyleneglycol dimethacrylate
KW - Polypropyleneglycol diacrylate
KW - Polypropyleneglycol dimethacrylate
UR - http://www.scopus.com/inward/record.url?scp=84949963931&partnerID=8YFLogxK
U2 - 10.1016/j.eurpolymj.2015.10.033
DO - 10.1016/j.eurpolymj.2015.10.033
M3 - Article
AN - SCOPUS:84949963931
SN - 0014-3057
VL - 75
SP - 25
EP - 35
JO - European Polymer Journal
JF - European Polymer Journal
ER -