Compressive strength and bioactivity properties of photopolymerizable hybrid composite hydrogels for bone tissue engineering

John A. Killion; Luke M. Geever; Declan M. Devine; Hugh Farrell; Clement L. Higginbotham

doi:10.1080/00914037.2013.854238

Compressive strength and bioactivity properties of photopolymerizable hybrid composite hydrogels for bone tissue engineering

John A. Killion, Luke M. Geever, Declan M. Devine, Hugh Farrell, Clement L. Higginbotham

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The drug release capabilities of synthetic bone scaffolds have often been overlooked. In this study novel poly(ethylene) glycol and beta-tricalcium phosphate hydrogel composites were photopolymerized and evaluated in terms of mechanical strength, bioactivity, antimicrobial release profile, and the efficacy of released antimicrobials. Young's modulus values ranged between 4.36 and 8.70 MPa. This increase was associated with the physical bonding interaction between polymer and bioceramic. Bioactivity was confirmed by the formation of globular crystals. Drug release studies showed the diffusion of vancomycin from hydrogel composites can be controlled by the hydrogels three-dimensional structure. Moreover, vancomycin loaded samples showed activity against Staphylococcus aureus.

Original language	English
Pages (from-to)	641-650
Number of pages	10
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	63
Issue number	13
DOIs	https://doi.org/10.1080/00914037.2013.854238
Publication status	Published - 2 Sep 2014

Keywords

Antimicrobials
biomineralization
drug release
hydrogels
mechanical properties
β-tricalcium phosphate

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10.1080/00914037.2013.854238

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title = "Compressive strength and bioactivity properties of photopolymerizable hybrid composite hydrogels for bone tissue engineering",

abstract = "The drug release capabilities of synthetic bone scaffolds have often been overlooked. In this study novel poly(ethylene) glycol and beta-tricalcium phosphate hydrogel composites were photopolymerized and evaluated in terms of mechanical strength, bioactivity, antimicrobial release profile, and the efficacy of released antimicrobials. Young's modulus values ranged between 4.36 and 8.70 MPa. This increase was associated with the physical bonding interaction between polymer and bioceramic. Bioactivity was confirmed by the formation of globular crystals. Drug release studies showed the diffusion of vancomycin from hydrogel composites can be controlled by the hydrogels three-dimensional structure. Moreover, vancomycin loaded samples showed activity against Staphylococcus aureus.",

keywords = "Antimicrobials, biomineralization, drug release, hydrogels, mechanical properties, β-tricalcium phosphate",

author = "Killion, {John A.} and Geever, {Luke M.} and Devine, {Declan M.} and Hugh Farrell and Higginbotham, {Clement L.}",

note = "Funding Information: This study was supported in part by grants from both the Irish Department of Education (Core Research Strengths Enhancement–Technological Sector Research: Strand III), the Athlone Institute of Technology Research and Development fund and the Marie Curie International Outgoing Fellowship within the 7th European Community Frame-work Programme.",

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doi = "10.1080/00914037.2013.854238",

language = "English",

volume = "63",

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Compressive strength and bioactivity properties of photopolymerizable hybrid composite hydrogels for bone tissue engineering. / Killion, John A.; Geever, Luke M.; Devine, Declan M. et al.
In: International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 63, No. 13, 02.09.2014, p. 641-650.

Research output: Contribution to journal › Article › peer-review

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AU - Killion, John A.

AU - Geever, Luke M.

AU - Devine, Declan M.

AU - Farrell, Hugh

AU - Higginbotham, Clement L.

N1 - Funding Information: This study was supported in part by grants from both the Irish Department of Education (Core Research Strengths Enhancement–Technological Sector Research: Strand III), the Athlone Institute of Technology Research and Development fund and the Marie Curie International Outgoing Fellowship within the 7th European Community Frame-work Programme.

PY - 2014/9/2

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AB - The drug release capabilities of synthetic bone scaffolds have often been overlooked. In this study novel poly(ethylene) glycol and beta-tricalcium phosphate hydrogel composites were photopolymerized and evaluated in terms of mechanical strength, bioactivity, antimicrobial release profile, and the efficacy of released antimicrobials. Young's modulus values ranged between 4.36 and 8.70 MPa. This increase was associated with the physical bonding interaction between polymer and bioceramic. Bioactivity was confirmed by the formation of globular crystals. Drug release studies showed the diffusion of vancomycin from hydrogel composites can be controlled by the hydrogels three-dimensional structure. Moreover, vancomycin loaded samples showed activity against Staphylococcus aureus.

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KW - biomineralization

KW - drug release

KW - hydrogels

KW - mechanical properties

KW - β-tricalcium phosphate

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Compressive strength and bioactivity properties of photopolymerizable hybrid composite hydrogels for bone tissue engineering

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