Biological evaluation and characterisation of novel hydrogel matrices as scaffolds for bone tissue engineering

Laura Grehan, John Killion, Sinead Devery, Clement Higginbotham, Luke Geever

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Citations (Scopus)

Abstract

Novel photo polymerised composite hydrogels based on PEGDMA, maleic chitosan and maleicPVA were investigated for their suitability in bone tissue engineering applications. Initial swellingand compression studies revealed that the hydrogels permitted the retention of aqueous solutionwhile still maintaining structural integrity. Promising cytotoxicity data was obtained during directand indirect contact exposure of composite hydrogels to pre-osteoblast (MC3T3-E1) cells. Hybridhydrogels displayed minimal cytotoxic properties and allow tailoring of mechanical properties byvariation of the loading of the maleic component in the composite. Scanning electron microscopyand live- dead staining of composite hydrogels also revealed that maleic chitosan based gelssupported the adhesion of MC3T3-E1 cells and may have potential as bone tissue engineeringscaffolds.

Original languageEnglish
Title of host publicationEngineering and Technology Research
EditorsMohd Mustafa Al Bakri Abdullah, Liyana Jamaludin, Muhammad Faheem Mohd Tahir, Mohd Najmuddin Mohd Hassan
PublisherTrans Tech Publications Ltd
Pages63-75
Number of pages13
ISBN (Electronic)9783038352792
DOIs
Publication statusPublished - 2014
Event4th International Malaysia-Ireland Joint Symposium on Engineering, Science and Business, IMiEJS 2014 - Penang, Malaysia
Duration: 25 Jun 201426 Jun 2014

Publication series

NameApplied Mechanics and Materials
Volume679
ISSN (Print)1660-9336
ISSN (Electronic)1662-7482

Conference

Conference4th International Malaysia-Ireland Joint Symposium on Engineering, Science and Business, IMiEJS 2014
Country/TerritoryMalaysia
CityPenang
Period25/06/1426/06/14

Keywords

  • Bone tissue engineering
  • Cell adhesion
  • Hydrogels
  • PEGDMA

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