TY - GEN
T1 - Biological evaluation and characterisation of novel hydrogel matrices as scaffolds for bone tissue engineering
AU - Grehan, Laura
AU - Killion, John
AU - Devery, Sinead
AU - Higginbotham, Clement
AU - Geever, Luke
N1 - Publisher Copyright:
©(2014) Trans Tech Publications, Switzerland
PY - 2014
Y1 - 2014
N2 - Novel photo polymerised composite hydrogels based on PEGDMA, maleic chitosan and maleicPVA were investigated for their suitability in bone tissue engineering applications. Initial swellingand compression studies revealed that the hydrogels permitted the retention of aqueous solutionwhile still maintaining structural integrity. Promising cytotoxicity data was obtained during directand indirect contact exposure of composite hydrogels to pre-osteoblast (MC3T3-E1) cells. Hybridhydrogels displayed minimal cytotoxic properties and allow tailoring of mechanical properties byvariation of the loading of the maleic component in the composite. Scanning electron microscopyand live- dead staining of composite hydrogels also revealed that maleic chitosan based gelssupported the adhesion of MC3T3-E1 cells and may have potential as bone tissue engineeringscaffolds.
AB - Novel photo polymerised composite hydrogels based on PEGDMA, maleic chitosan and maleicPVA were investigated for their suitability in bone tissue engineering applications. Initial swellingand compression studies revealed that the hydrogels permitted the retention of aqueous solutionwhile still maintaining structural integrity. Promising cytotoxicity data was obtained during directand indirect contact exposure of composite hydrogels to pre-osteoblast (MC3T3-E1) cells. Hybridhydrogels displayed minimal cytotoxic properties and allow tailoring of mechanical properties byvariation of the loading of the maleic component in the composite. Scanning electron microscopyand live- dead staining of composite hydrogels also revealed that maleic chitosan based gelssupported the adhesion of MC3T3-E1 cells and may have potential as bone tissue engineeringscaffolds.
KW - Bone tissue engineering
KW - Cell adhesion
KW - Hydrogels
KW - PEGDMA
UR - http://www.scopus.com/inward/record.url?scp=84920815798&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/AMM.679.63
DO - 10.4028/www.scientific.net/AMM.679.63
M3 - Conference contribution
AN - SCOPUS:84920815798
T3 - Applied Mechanics and Materials
SP - 63
EP - 75
BT - Engineering and Technology Research
A2 - Abdullah, Mohd Mustafa Al Bakri
A2 - Jamaludin, Liyana
A2 - Tahir, Muhammad Faheem Mohd
A2 - Hassan, Mohd Najmuddin Mohd
PB - Trans Tech Publications Ltd
T2 - 4th International Malaysia-Ireland Joint Symposium on Engineering, Science and Business, IMiEJS 2014
Y2 - 25 June 2014 through 26 June 2014
ER -