TY - JOUR
T1 - A systematic review of mucoadhesive vaginal tablet testing
AU - Abidin, Ismin Zainol
AU - Murphy, Emma J.
AU - Fehrenbach, Gustavo Waltzer
AU - Rezoagli, Emanuele
AU - Gately, Noel
AU - Major, Ian
N1 - Publisher Copyright:
© 2023 The Authors.
PY - 2023
Y1 - 2023
N2 - Drug administration through the vaginal tract is one of the oldest modalities of pharmacotherapy, and it is also one of the most explored. Since the vaginal cavity has a wide surface area, a plentiful blood supply, and a complex network of blood arteries, it can evade hepatic first-pass metabolism and obtain high local drug concentrations. Vaginal pills look to be a good dose form since they are simple to use, portable, and can easily deliver the required amount of medicine. Vaginal formulations, on the other hand, are vulnerable to rapid expulsion due to the vaginal tract’s self-cleaning action, which reduces the formulation’s efficiency. Currently, there is an increasing amount of focus on mucoadhesive vaginal formulation research and development to fix the formulation at the place where the medicine can be released and/or absorbed. This article examines all of the strategies used by researchers to develop a mucoadhesive vaginal tablet that is safe, effective, and comfortable for the user.
AB - Drug administration through the vaginal tract is one of the oldest modalities of pharmacotherapy, and it is also one of the most explored. Since the vaginal cavity has a wide surface area, a plentiful blood supply, and a complex network of blood arteries, it can evade hepatic first-pass metabolism and obtain high local drug concentrations. Vaginal pills look to be a good dose form since they are simple to use, portable, and can easily deliver the required amount of medicine. Vaginal formulations, on the other hand, are vulnerable to rapid expulsion due to the vaginal tract’s self-cleaning action, which reduces the formulation’s efficiency. Currently, there is an increasing amount of focus on mucoadhesive vaginal formulation research and development to fix the formulation at the place where the medicine can be released and/or absorbed. This article examines all of the strategies used by researchers to develop a mucoadhesive vaginal tablet that is safe, effective, and comfortable for the user.
KW - Dissolution
KW - Mucoadhesion
KW - Physicochemical
KW - Swelling
UR - http://www.scopus.com/inward/record.url?scp=85146804043&partnerID=8YFLogxK
U2 - 10.33393/dti.2023.2477
DO - 10.33393/dti.2023.2477
M3 - Review article
AN - SCOPUS:85146804043
SN - 1177-3928
VL - 17
SP - 5
EP - 30
JO - Drug Target Insights
JF - Drug Target Insights
ER -